研究業績

2023年

学術論文

• "Identification of a tomato UDP-arabinosyltransferase for airborne volatile reception"
  Sugimoto K, Ono E, Inaba T, Tsukahara T, Matsui K, Horikawa M, Toyonaga H, Fujikawa K, Osawa T, Homma S, Kiriiwa Y, Ohmura I, Miyagawa A, Yamamura H, Fujii M, Ozawa R, Watanabe B, Miura K, Ezura H, Ohnishi T, Takabayashi J.
  Nature Communications 14, 677 (2023).

  • DOI: 10.1038/s41467-023-36381-8

2022年

学術論文

• "Photostable Abscisic Acid Agonists with a Geometrically Rigid Cyclized Side Chain"
  Takeuchi J, Mimura S, Ohnishi T, Todoroki Y.
  J Agric Food Chem 70, 3, 869-876 (2022).

  • DOI: 10.1021/acs.jafc.1c06321
• "1-Octen-3-ol is formed from its primeveroside after mechanical wounding of soybean leaves"
  Ntoruru JM, Ohnishi T, Katsumata F, Koeduka T, Matsui K.
  Plant Mol Biol 109, 551_561 (2022).

  • DOI: 10.1007/s11103-021-01226-9

2021年

学術論文

• "Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo"
  Vaidya AS, Peterson FC, Eckhardt J, Xing Z, Park SY, Dejonghe W, Takeuchi J, Pri-Tal O, Faria J, Elzinga D, Volkman BF, Todoroki Y, Mosquna A, Okamoto M, Cutler SR.
  Proc Natl Acad Sci U S A 18, 38, e2108281118 (2021).

  • DOI: 10.1073/pnas.2108281118
• "Tissue-Dependent Variation Profiles of Tea Quality-Related Metabolites in New Shoots of Tea Accessions"
  Yamashita H, Katai H, Ohnishi T, Morita A, Panda SK, Ikka T.
  Front Nutr 8, 659807 (2021).

  • DOI: 10.3389/fnut.2021.659807
• "Keeping the shoot above water - submergence triggers antithetical growth responses in stems and petioles of watercress (Nasturtium officinale)"
  M?ller JT, van Veen H, Bartylla MM, Akman M, Pedersen O, Sun P, Schuurink RC, Takeuchi J, Todoroki Y, Weig AR, Sasidharan R, Mustroph A.
  New Phytol (2021).

  • DOI: 10.1111/nph.16350

2020年

学術論文

• "Molecular cloning and characterization of UDP-glucose: Volatile benzenoid/phenylpropanoid glucosyltransferase in petunia flowers"
  Koeduka T, Ueyama Y, Kitajima S, Ohnishi T, Matsui K.
  J Plant Physiol 252, 153245 (2020).

  • DOI: 10.1016/j.jplph.2020.153245
• "Design of potent ABA receptor antagonists based on a conformational restriction approach"
  Takeuchi J, Nagamiya H, Moroi S, Ohnishi T, Todoroki Y.
  Org Biomol Chem 18, 4988-4996 (2020).

  • DOI: 10.1039/d0ob01017k
• "Rhizotaxis Modulation in Arabidopsis Is Induced by Diffusible Compounds Produced during the Cocultivation of Arabidopsis and the Endophytic Fungus Serendipita indica"
  Inaji A, Okazawa A, Taguchi T, Nakamoto M, Katsuyama N, Yoshikawa R, Ohnishi T, Waller F, Ohta D.
  Plant Cell Physiol 61, 4, 838-850 (2020).

  • DOI: 10.1093/pcp/pcaa008

総説 (日本語)

• "植物の「香り」の貯蔵の仕組み－「香り」を利用した植物の環境ストレスマネージメント"
  大西利幸
  AROMA RESEARCH 19, 22-24 (2020).

2019年

学術論文

• "Dynamic control of plant water use using designed ABA receptor agonists"
  Vaidya AS, Helander JDM, Peterson FC, Elzinga D, Dejonghe W, Kaundal A, Park SY, Xing Z, Mega R, Takeuchi J, Khanderahoo B, Bishay S, Volkman BF, Todoroki Y, Okamoto M, Cutler SR.
  Science (2019).

  • DOI: 10.1126/science.aaw8848
• "Overexpression of geraniol synthase induces heat stress susceptibility in Nicotiana tabacum"
  Hamachi A, Nisihara M, Saito S, Rim H, Takahashi H, Islam M, Uemura T, Ohnishi T, Ozawa R, Maffei ME, Arimura GI.
  Planta 249, 1, 235-249 (2019).

  • DOI: 10.1007/s00425-018-3054-z

総説 (日本語)

• "茶の「香り」の貯蔵と生成のメカニズム"
  大西利幸
  香料 284, 29-37 (2019).
• "「香り」や香気配糖体が織りなす化学防御システム ―「香り」や香気配糖体が植物の身を守る―"
  大西利幸
  日本農薬学会誌 43, 65-66 (2019).

  • DOI: 10.1584/jpestics.W19-05

2018年

学術論文

• "Recent advances in brassinosteroid biosynthetic pathway: insight into novel brassinosteroid shortcut pathway"
  Ohnishi T.
  J Pestic Sci 43, 3, 235-249 (2018).

  • DOI: 10.1584/jpestics.D18-040
• "Identification of a Hexenal Reductase That Modulates the Composition of Green Leaf Volatiles"
  Tanaka T, Ikeda A, Shiojiri K, Ozawa R, Shiki K, Nagai-Kunihiro N, Fujita K, Sugimoto K, Yamato KT, Dohra H, Ohnishi T, Koeduka T, Matsui K.
  Plant Physiol 178, 2, 552-564 (2018).

  • DOI: 10.1104/pp.18.00632
• "Silkworms suppress the release of green leaf volatiles by mulberry leaves with an enzyme from their spinnerets"
  Takai H, Ozawa R, Takabayashi J, Fujii S, Arai K, Ichiki RT, Koeduka T, Dohra H, Ohnishi T, Taketazu S, Kobayashi J, Kainoh Y, Nakamura S, Fujii T, Ishikawa Y, Kiuchi T, Katsuma S, Uefune M, Shimada T, Matsui K.
  Sci Rep 8, 1, 1月14日 (2018).

  • DOI: 10.1038/s41598-018-30328-6
• "1-Octen-3-ol Is Formed from Its Glycoside during Processing of Soybean [ Glycine max (L.) Merr.] Seeds"
  Matsui K, Takemoto H, Koeduka T, Ohnishi T.
  J Agric Food Chem 66, 28, 7409-7416 (2018).

  • DOI: 10.1021/acs.jafc.8b01950
• "Structure-Based Chemical Design of Abscisic Acid Antagonists That Block PYL-PP2C Receptor Interactions"
  Takeuchi J, Mimura N, Okamoto M, Yajima S, Sue M, Akiyama T, Monda K, Iba K, Ohnishi T, Todoroki Y.
  ACS Chem Biol (2018).

  • DOI: 10.1021/acschembio.8b00105
• "The effects of gene disruption of Kre6-like proteins on the phenotype of β-glucan-producing Aureobasidium pullulans"
  Uchiyama H, Iwai A, Dohra H, Ohnishi T, Kato T, Park EY.
  Appl Microbiol Biotechnol 102, 10, 4467-4475 (2018).

  • DOI: 10.1007/s00253-018-8947-z
• "Conversion of carlactone to carlactonoic acid is a conserved function of MAX1 homologs in strigolactone biosynthesis"
  Yoneyama K, Mori N, Sato T, Yoda A, Xie X, Okamoto M, Iwanaga M, Ohnishi T, Nishiwaki H, Asami T, Yokota T, Akiyama K, Yoneyama K, Nomura T.
  New Phytol 218, 4, 1522-1533 (2018).

  • DOI: 10.1111/nph.15055

総説 (日本語)

• "紅茶と烏龍茶の「香り」の生成メカニズムの違い － 香気配糖体は「香り」の源なのか？"
  大西利幸
  FFIジャーナル 223, 2, 99-105 (2018).

2017年

学術論文

• "'Hidden' Terpenoids in Plants: Their Biosynthesis, Localization and Ecological Roles"
  Yazaki K, Arimura GI, Ohnishi T.
  Plant Cell Physiol 58, 10, 1615-1621 (2017).

  • DOI: 10.1093/pcp/pcx123
• "Occurrence of brassinosteroids in non-flowering land plants, liverwort, moss, lycophyte and fern"
  Yokota T, Ohnishi T, Shibata K, Asahina M, Nomura T, Fujita T, Ishizaki K, Kohchi T.
  Phytochemistry 136, 46-55 (2017).

  • DOI: 10.1016/j.phytochem.2016.12.020
• "Generation of a novel artificial TrkB agonist, BM17d99, using T7 phage-displayed random peptide libraries"
  Ohnishi T, Sakamoto K, Asami-Odaka A, Nakamura K, Shimizu A, Ito T, Asami T, Ohtaki T, Inooka H.
  Biochem Biophys Res Commun (2017).

  • DOI: 10.1016/j.bbrc.2016.12.186

総説 (日本語)

• "植物の「香り」の配糖化メカニズム"
  大西利幸
  植物の生長調節 52, 2, 99-105 (2017).

  • DOI: 10.18978/jscrp.52.2_99

2016年

学術論文

• "Synthesis and herbicidal activity of 3-{[(hetero)aryl]methanesulfonyl}-4,5-dihydro-1,2-oxazole derivative; Discovery of the novel pre-emergence herbicide pyroxasulfone"
  Araki Y, Miyawaki A, Miyashita T, Mizutani M, Hirai N, Todoroki Y.
  J Pestic Sci (2016).

  • DOI: 10.1584/jpestics.D15-078
• "Abscinazole-E3M, a practical inhibitor of abscisic acid 8'-hydroxylase for improving drought tolerance"
  Takeuchi J, Okamoto M, Mega R, Kanno Y, Ohnishi T, Seo M, Todoroki Y.
  Sci Rep 14, 6, 37060- (2016).

  • DOI: 10.1038/srep37060
• "Biosynthesis of floral scent 2-phenylethanol in rose flowers"
  Hirata H, Ohnishi T, Watanabe N.
  Biosci Biotechnol Biochem 80, 10, 1865-1873 (2016).

  • DOI: 10.1080/09168451.2016.1191333
• "Seasonal induction of alternative principal pathway for rose flower scent"
  Hirata H, Ohnishi T, Tomida K, Ishida H, Kanda M, Sakai M, Yoshimura J, Suzuki H, Ishikawa T, Dohra H, Watanabe N.
  Sci Rep 20234 (2016).

  • DOI: 10.1038/srep20234
• "Characteristic Fluctuations in Glycosidically Bound Volatiles during Tea Processing and Identification of Their Unstable Derivatives"
  Cui J, Katsuno T, Totsuka K, Ohnishi T, Takemoto H, Mase N, Toda M, Narumi T, Sato K, Matsuo T, Mizutani K, Yang Z, Watanabe N, Tong H.
  J Agric Food Chem 64, 5, 1151-1157 (2016).

  • DOI: 10.1021/acs.jafc.5b05072
• "Biosynthesis of floral scent 2-phenylethanol in rose flowers."
  Hirata H, Ohnishi T, Watanabe N.
  Biosci Biotechnol Biochem. 80, 10, 1865-73 (2016).

  • DOI: 10.1080/09168451.2016.1191333.

総説 (日本語)

• "茶の香り成分の貯蔵に関わる配糖体化酵素の解明"
  大西利幸
  バイオサイエンスとインダストリー 74, 2, 129-131 (2016).

2015年

学術論文

• "Lactic acid is a sperm motility inactivation factor in the sperm storage tubules"
  Matsuzaki M, Mizushima S, Hiyama G, Hirohashi N, Shiba K, Inaba K, Suzuki T, Dohra H, Ohnishi T, Sato Y, Kohsaka T, Ichikawa Y, Atsumi Y, Yoshimura T, Sasanami T.
  Sci Rep 17643 (2015).

  • DOI: 10.1038/srep17643
• "A Conserved Cytochrome P450 Evolved in Seed Plants Regulates Flower Maturation"
  Liu Z, Boachon B, Lugan R, Tavares R, Erhardt M, Mutterer J, Demais V, Pateyron S, Brunaud V, Ohnishi T, Pencik A, Achard P, Gong F, Hedden P, Werck-Reichhart D, Renault H.
  Mol Plant 2052, 2, 00363-00369 (2015).

  • DOI: 10.1016/j.molp.2015.09.002
• "The selectivity of 6-nor-ABA and 7'-nor-ABA for abscisic acid receptor subtypes"
  Takeuchi J, Ohnishi T, Okamoto M, Todoroki Y.
  Bioorg Med Chem Lett 25, 17, 3507-3510 (2015).

  • DOI: 10.1016/j.bmcl.2015.06.088
• "Cyanamide is biosynthesized from L-canavanine in plants"
  Kamo T, Sakurai S, Yamanashi T, Todoroki Y.
  Sci Rep (2015).

  • DOI: 10.1038/srep10527
• "Volatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are Catalyzed by Two Camellia sinensis Glycosyltransferases"
  Ohgami S, Ono E, Horikawa M, Murata J, Totsuka K, Toyonaga H, Ohba Y, Dohra H, Asai T, Matsui K, Mizutani M, Watanabe N, Ohnishi T.
  Plant Physiol 168, 2, 464-477 (2015).

  • DOI: 10.1104/pp.15.00403
• "Conformationally restricted 3'-modified ABA analogs for controlling ABA receptors"
  Takeuchi J, Ohnishi T, Okamoto M, Todoroki Y.
  Org Biomol Chem 13, 14, 4278-4288 (2015).

  • DOI: 10.1039/c4ob02662d
• "Identification and characterization of Camellia sinensis glucosyltransferase, UGT73A17: a possible role in flavonol glucosylation"
  Ohgami S,Ono E,Toyonaga H,Watanabe N,Ohnsihi T
  Plant Biotechnology (2015).

  • DOI: 10.5511/plantbiotechnology.14.1027a
• "Characterization of flower-inducing compound in Lemna paucicostata exposed to drought stress"
  Murata A,Akaike R,Ohnishi T,Winterhalter P,Watanabe N
  TETRAHEDRON 70, 33, 4969-4976 (2015).

  • DOI: 10.1016/j.tet.2014.03.099

総説 (日本語)

• "植物の生長および化学防御に関わるテルペノイド生合成の生物有機化学的研究"
  大西利幸
  植物の生長調節 50, 1, 28-39 (2015).

  • DOI: 10.18978/jscrp.50.1_28

2014年

学術論文

• "Carlactone is converted to carlactonoic acid by MAX1 in Arabidopsis and its methyl ester can directly interact with AtD14 in vitro"
  Abe S, Sado A, Tanaka K, Kisugi T, Asami K, Ota S, Kim HI, Yoneyama K, Xie X, Ohnishi T, Seto Y, Yamaguchi S, Akiyama K, Yoneyama K, Nomura T.
  Proc Natl Acad Sci U S A 111, 50, 18084-18089 (2014).

  • DOI: 10.1073/pnas.1410801111
• "Designed abscisic acid analogs as antagonists of PYL-PP2C receptor interactions"
  Takeuchi J, Okamoto M, Akiyama T, Muto T, Yajima S, Sue M, Seo M, Kanno Y, Kamo T, Endo A, Nambara E, Hirai N, Ohnishi T, Cutler SR, Todoroki Y.
  Nat Chem Biol (2014).

  • DOI: 10.1038/nchembio.1524
• "Metabolism of bisphenol A by hyper lignin-degrading fungus Phanerochaete sordida YK-624 under non-ligninolytic condition"
  Wang J, Yamada Y, Notake A, Todoroki Y, Tokumoto T, Dong J, Thomas P, Hirai H, Kawagishi H.
  Chemosphere (2014).

  • DOI: 10.1016/j.chemosphere.2014.01.029
• "The source of "fairy rings": 2-azahypoxanthine and its metabolite found in a novel purine metabolic pathway in plants"
  Choi JH, Ohnishi T, Yamakawa Y, Takeda S, Sekiguchi S, Maruyama W, Yamashita K, Suzuki T, Morita A, Ikka T, Motohashi R, Kiriiwa Y, Tobina H, Asai T, Tokuyama S, Hirai H, Yasuda N, Noguchi K, Asakawa T, Sugiyama S, Kan T, Kawagishi H.
  Angew Chem Int Ed Engl 53, 6, 1552-1555 (2014).

  • DOI: 10.1002/anie.201308109
• "Rationally designed abscisic acid analogues as antagonists of PYL-PP2C receptor interactions"
  Takeuchi J,Okamoto M,Ohnishi T,Cutler SR,Todoroki Y
  Nature Chemical Biology 10, 6, 477-482 (2014).

  • DOI: 10.1038/nchembio.1524
• "Characterisation of odorant compounds and their biochemical formation in green tea with a low temperature storage process"
  Katsuno T, Kasuga H, Kusano Y, Yaguchi Y, Tomomura M, Cui J, Yang Z, Baldermann S, Nakamura Y, Ohnishi T, Mase N, Watanabe N.
  Food Chem 148, 388-395 (2014).

  • DOI: 10.1016/j.foodchem.2013.10.069

2013年

学術論文

• "Purification and gas chromatography-combustion-isotope ratio mass spectrometry of aroma compounds from green tea products and comparison to bulk analysis"
  Murata A, Engelhardt UH, Fleischmann P, Yamada K, Yoshida N, Juchelka D, Hilkert A, Ohnishi T, Watanabe N, Winterhalter P.
  J Agric Food Chem 61, 47, 11321-11325 (2013).

  • DOI: 10.1021/jf403605a
• "CYP345E2, an antenna-specific cytochrome P450 from the mountain pine beetle, Dendroctonus ponderosae Hopkins, catalyses the oxidation of pine host monoterpene volatiles"
  Keeling CI, Henderson H, Li M, Dullat HK, Ohnishi T, Bohlmann J.
  Insect Biochem Mol Biol 43, 12, 1142-1151 (2013).

  • DOI: 10.1016/j.ibmb.2013.10.001
• "Enhancement of production of eugenol and its glycosides in transgenic aspen plants via genetic engineering"
  Koeduka T, Suzuki S, Iijima Y, Ohnishi T, Suzuki H, Watanabe B, Shibata D, Umezawa T, Pichersky E, Hiratake J.
  Biochem Biophys Res Commun 436, 1, 73-78 (2013).

  • DOI: 10.1016/j.bbrc.2013.05.060
• "Brassinolide-2,3-acetonide: a brassinolide-induced rice lamina joint inclination antagonist"
  Muto T, Todoroki Y.
  Bioorg Med Chem (2013).

  • DOI: 10.1016/j.bmc.2013.04.048
• "CYP714B1 and CYP714B2 encode gibberellin 13-oxidases that reduce gibberellin activity in rice"
  Magome H, Nomura T, Hanada A, Takeda-Kamiya N, Ohnishi T, Shinma Y, Katsumata T, Kawaide H, Kamiya Y, Yamaguchi S.
  Proc Natl Acad Sci U S A 110, 5, 1947-1952 (2013).

  • DOI: 10.1073/pnas.1215788110
• "Influence of exogenously applied abscisic acid on carotenoid content and water uptake in flowers of the tea plant (Camellia sinensis)"
  Baldermann S, Yang Z, Sakai M, Fleischmann P, Morita A, Todoroki Y, Watanabe N.
  J Sci Food Agric (2013).

  • DOI: 10.1002/jsfa.5944

2012年

学術論文

• "PrCYP707A1, an ABA catabolic gene, is a key component of Phelipanche ramosa seed germination in response to the strigolactone analogue GR24"
  Lechat MM, Pouvreau JB, P?ron T, Gauthier M, Montiel G, V?ron?si C, Todoroki Y, Le Bizec B, Monteau F, Macherel D, Simier P, Thoiron S, Delavault P.
  J Exp Bot (2012).

  • DOI: 10.1093/jxb/ers189
• "Rice CYP90D2 and CYP90D3 catalyze C-23 hydroxylation of brassinosteroids in vitro"
  Sakamoto T, Ohnishi T, Fujioka S, Watanabe B, Mizutani M.
  Plant Physiol Biochem 58, 220-226 (2012).

  • DOI: 10.1016/j.plaphy.2012.07.011
• "CYP90A1/CPD, a brassinosteroid biosynthetic cytochrome P450 of Arabidopsis, catalyzes C-3 oxidation"
  Ohnishi T, Godza B, Watanabe B, Fujioka S, Hategan L, Ide K, Shibata K, Yokota T, Szekeres M, Mizutani M.
  J Biol Chem 287, 37, 31551-31560 (2012).

  • DOI: 10.1074/jbc.M112.392720
• "Electrolytic reduction of abscisic acid methyl ester and its free acid"
  Hirai N, Iwami K, Horiuchi M, Kano K, Todoroki Y, Ohigashi H.
  Phytochemistry (2012).

  • DOI: 10.1016/j.phytochem.2012.04.010
• "Abscinazole-E2B, a practical and selective inhibitor of ABA 8'-hydroxylase CYP707A"
  Okazaki M, Kittikorn M, Ueno K, Mizutani M, Hirai N, Kondo S, Ohnishi T, Todoroki Y.
  Bioorg Med Chem 20, 10, 3162-3172 (2012).

  • DOI: 10.1016/j.bmc.2012.03.068
• "A conformationally restricted uniconazole analogue as a specific inhibitor of rice ent-kaurene oxidase, CYP701A6"
  Todoroki Y, Naiki K, Muramatsu T, Ohnishi T, Ueno K, Mizutani M, Hirai N.
  Bioorg Med Chem Lett 22, 9, 3240-3243 (2012).

  • DOI: 10.1016/j.bmcl.2012.03.028
• "Functional characterization of aromatic amino acid aminotransferase involved in 2-phenylethanol biosynthesis in isolated rose petal protoplasts"
  Hirata H, Ohnishi T, Ishida H, Tomida K, Sakai M, Hara M, Watanabe N.
  J Plant Physiol 169, 5, 444-451 (2012).

  • DOI: 10.1016/j.jplph.2011.12.005
• "Characterization of L-phenylalanine metabolism to acetophenone and 1-phenylethanol in the flowers of Camellia sinensis using stable isotope labeling"
  Dong F, Yang Z, Baldermann S, Kajitani Y, Ota S, Kasuga H, Imazeki Y, Ohnishi T, Watanabe N.
  J Plant Physiol 169, 3, 217-225 (2012).

  • DOI: 10.1016/j.jplph.2011.12.003
• "Dehydration tolerance in apple seedlings is affected by an inhibitor of ABA 8'-hydroxylase CYP707A"
  Kondo S, Sugaya S, Sugawa S, Ninomiya M, Kittikorn M, Okawa K, Ohara H, Ueno K, Todoroki Y, Mizutani M, Hirai N.
  J Plant Physiol (2012).

  • DOI: 10.1016/j.jplph.2011.09.007

総説 (日本語)

• "針葉樹の化学防御物質ジテルペン樹脂酸の生合成"
  大西利幸
  バイオサイエンスとインダストリー 70, 5, 365-369 (2012).

  • DOI: 10.14841/jspp.2009.0.0207.0
• "香りの生合成経路が季節によって変わる"
  大西利幸
  化学と生物 50, 8, 570-576 (2012).

  • DOI: 10.1271/kagakutoseibutsu.50.570
• "植物由来のテルペンを介したEcological volatiles その分子基盤"
  大西利幸
  植物の生長調節 46, 1, 58-67 (2012).

  • DOI: 10.18978/jscrp.46.1_58
• "植物をもっとグリーンにする～環境負荷を与える揮発性化合物の抑制"
  肥塚崇男, 大西利幸, 松井健二
  アロマリサーチ 13, 4 (2012).

2011年

学術論文

• "Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin"
  Seki H, Sawai S, Ohyama K, Mizutani M, Ohnishi T, Sudo H, Fukushima EO, Akashi T, Aoki T, Saito K, Muranaka T.
  Plant Cell 23, 11, 4112-4123 (2011).

  • DOI: 10.1105/tpc.110.082685
• "Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects"
  Hamberger B, Ohnishi T, Hamberger B, S?guin A, Bohlmann J.
  Plant Physiol 157, 4, 1677-1695 (2011).

  • DOI: 10.1104/pp.111.185843
• "Synthesis and biological activity of amino acid conjugates of abscisic acid"
  Todoroki Y, Narita K, Muramatsu T, Shimomura H, Ohnishi T, Mizutani M, Ueno K, Hirai N.
  Bioorg Med Chem 19, 5, 1743-1750 (2011).

  • DOI: 10.1016/j.bmc.2011.01.019
• "Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8'-hydroxylase CYP707A"
  Okazaki M, Nimitkeatkai H, Muramatsu T, Aoyama H, Ueno K, Mizutani M, Hirai N, Kondo S, Ohnishi T, Todoroki Y.
  Bioorg Med Chem 19, 1, 406-413 (2011).

  • DOI: 10.1016/j.bmc.2010.11.011
• "Functional characterization of rose phenylacetaldehyde reductase (PAR), an enzyme involved in the biosynthesis of the scent compound 2-phenylethanol"
  Chen XM, Kobayashi H, Sakai M, Hirata H, Asai T, Ohnishi T, Baldermann S, Watanabe N.
  J Plant Physiol 168, 2, 88-95 (2011).

  • DOI: 10.1016/j.jplph.2010.06.011

2010年

学術論文

• "Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole"
  Todoroki Y, Naiki K, Aoyama H, Shirakura M, Ueno K, Mizutani M, Hirai N.
  Bioorg Med Chem Lett (2010).

  • DOI: 10.1016/j.bmcl.2010.07.067

2009年

学術論文

• "Insights into the function and evolution of P450s in plant steroid metabolism"
  Ohnishi T, Yokota T, Mizutani M.
  Phytochemistry 70, 17-18, 1918-1929 (2009).

  • DOI: 10.1016/j.phytochem.2009.09.015
• "Enlarged analogues of uniconazole, new azole containing inhibitors of ABA 8'-hydroxylase CYP707A"
  Todoroki Y, Aoyama H, Hiramatsu S, Shirakura M, Nimitkeatkai H, Kondo S, Ueno K, Mizutani M, Hirai N.
  Bioorg Med Chem Lett (2009).

  • DOI: 10.1016/j.bmcl.2009.07.137
• "Abscinazole-F1, a conformationally restricted analogue of the plant growth retardant uniconazole and an inhibitor of ABA 8'-hydroxylase CYP707A with no growth-retardant effect"
  Todoroki Y, Kobayashi K, Shirakura M, Aoyama H, Takatori K, Nimitkeatkai H, Jin MH, Hiramatsu S, Ueno K, Kondo S, Mizutani M, Hirai N.
  Bioorg Med Chem (2009).

  • DOI: 10.1016/j.bmc.2009.07.070

2008年

学術論文

• "Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin"
  Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T.
  Proc Natl Acad Sci U S A 105, 37, 14204-14209 (2008).

  • DOI: 10.1073/pnas.0803876105
• "Brz220 interacts with DWF4, a cytochrome P450 monooxygenase in brassinosteroid biosynthesis, and exerts biological activity"
  Sekimata K, Ohnishi T, Mizutani M, Todoroki Y, Han SY, Uzawa J, Fujioka S, Yoneyama K, Takeuchi Y, Takatsuto S, Sakata K, Yoshida S, Asami T.
  Biosci Biotechnol Biochem 72, 1, 7月12日 (2008).

  • DOI: 10.1271/bbb.70141
• "Structure-activity relationship of uniconazole, a potent inhibitor of ABA 8'-hydroxylase, with a focus on hydrophilic functional groups and conformation"
  Todoroki Y, Kobayashi K, Yoneyama H, Hiramatsu S, Jin MH, Watanabe B, Mizutani M, Hirai N.
  Bioorg Med Chem (2008).

  • DOI: 10.1016/j.bmc.2007.12.019

2007年

学術論文

• "Asymmetrical ligand binding by abscisic acid 8'-hydroxylase"
  Ueno K, Yoneyama H, Mizutani M, Hirai N, Todoroki Y.
  Bioorg Med Chem (2007).

  • DOI: 10.1016/j.bmc.2007.06.010
• "Effect of the minor ABA metabolite 7'-hydroxy-ABA on Arabidopsis ABA 8'-hydroxylase CYP707A3"
  Shimomura H, Etoh H, Mizutani M, Hirai N, Todoroki Y.
  Bioorg Med Chem Lett (2007).

  • DOI: 10.1016/j.bmcl.2007.06.018

2006年

学術論文

• "C-23 hydroxylation by Arabidopsis CYP90C1 and CYP90D1 reveals a novel shortcut in brassinosteroid biosynthesis"
  Ohnishi T, Szatmari AM, Watanabe B, Fujita S, Bancos S, Koncz C, Lafos M, Shibata K, Yokota T, Sakata K, Szekeres M, Mizutani M.
  Plant Cell 18, 11, 3275-3288 (2006).

  • DOI: 10.1105/tpc.106.045443
• "CYP724B2 and CYP90B3 function in the early C-22 hydroxylation steps of brassinosteroid biosynthetic pathway in tomato"
  Ohnishi T, Watanabe B, Sakata K, Mizutani M.
  Biosci Biotechnol Biochem 70, 9, 2071-2080 (2006).

  • DOI: 10.1271/bbb.60034
• "Tomato cytochrome P450 CYP734A7 functions in brassinosteroid catabolism"
  Ohnishi T, Nomura T, Watanabe B, Ohta D, Yokota T, Miyagawa H, Sakata K, Mizutani M.
  Phytochemistry 67, 17, 1895-1906 (2006).

  • DOI: 10.1016/j.phytochem.2006.05.042
• "A plant growth retardant, uniconazole, is a potent inhibitor of ABA catabolism in Arabidopsis"
  Saito S, Okamoto M, Shinoda S, Kushiro T, Koshiba T, Kamiya Y, Hirai N, Todoroki Y, Sakata K, Nambara E, Mizutani M.
  Biosci Biotechnol Biochem (2006).

  • DOI: 10.1271/bbb.60077
• "A new non-azole inhibitor of ABA 8'-hydroxylase: effect of the hydroxyl group substituted for geminal methyl groups in the six-membered ring"
  Araki Y, Miyawaki A, Miyashita T, Mizutani M, Hirai N, Todoroki Y.
  Bioorg Med Chem Lett (2006).

  • DOI: 10.1016/j.bmcl.2006.03.024
• "Arabidopsis CYP90B1 catalyses the early C-22 hydroxylation of C27, C28 and C29 sterols"
  Fujita S, Ohnishi T, Watanabe B, Yokota T, Takatsuto S, Fujioka S, Yoshida S, Sakata K, Mizutani M.
  Plant J 45, 5, 765-774 (2006).

  • DOI: 10.1111/j.1365-313X.2005.02639.x
• "Erect leaves caused by brassinosteroid deficiency increase biomass production and grain yield in rice"
  Sakamoto T, Morinaka Y, Ohnishi T, Sunohara H, Fujioka S, Ueguchi-Tanaka M, Mizutani M, Sakata K, Takatsuto S, Yoshida S, Tanaka H, Kitano H, Matsuoka M.
  Nat Biotechnol 24, 1, 105-109 (2006).

  • DOI: 10.1038/nbt1173

2005年

学術論文

• "A lead compound for the development of ABA 8'-hydroxylase inhibitors"
  Ueno K, Yoneyama H, Saito S, Mizutani M, Sakata K, Hirai N, Todoroki Y.
  Bioorg Med Chem Lett (2005).

  • DOI: 10.1016/j.bmcl.2005.08.042
• "Differences between the structural requirements for ABA 8'-hydroxylase inhibition and for ABA activity"
  Ueno K, Araki Y, Hirai N, Saito S, Mizutani M, Sakata K, Todoroki Y.
  Bioorg Med Chem (2005).

  • DOI: 10.1016/j.bmc.2005.03.015

2004年

学術論文

• "Metabolism of 5'alpha,8'-cycloabscisic acid, a highly potent and long-lasting abscisic acid analogue, in radish seedlings"
  Todoroki Y, Sawada M, Matsumoto M, Tsukada S, Ueno K, Isaka M, Owaki M, Hirai N.
  Bioorg Med Chem (2004).

  • DOI: 10.1016/j.bmc.2003.10.048

2003年

学術論文

• "Endogenous alpha-ketol linolenic acid levels in short day-induced cotyledons are closely related to flower induction in Pharbitis nil"
  Suzuki M, Yamaguchi S, Iida T, Hashimoto I, Teranishi H, Mizoguchi M, Yano F, Todoroki Y, Watanabe N, Yokoyama M.
  Plant Cell Physiol (2003).

  • DOI: 10.1093/pcp/pcg007